Recombinant Nucleosome Quality Control Materials for ctDNA Molecular Profiling: Control from Sample, DNA Extraction, Library Prep, Sequencing to Data Analysis
Time: 12:00 pm
day: Day Two Track A (AM)
Details:
- Quality control is an essential step in any NGS workflow; allowing the integrity and quality of data to be checked before analysis and interpretation. Currently, there is not a standardised method nor material to control the whole workflow, from blood collection to bioinformatic analysis
- Volition has developed a unique reference material made of recombinant nucleosomes in plasma. The advantage of using recombinant nucleosome is that the cfDNA will be analyzed in its native nucleosomal format, whereas existing reference materials are only composed of DNA
- Those recombinant nucleosomes can be processed in parallel to patient samples, from DNA extraction to final results. It can address any kind of genomic alteration at any Mutated Allelic Fraction
