Leighla Tayefeh

Leighla Tayefeh

Company: Ionis Pharmaceuticals

Job title: Research Associate, Biomarker Development


As a member of the Biomarker development team at Ionis Pharmaceuticals, Leighla is responsible for assay development working closely with various groups internally to develop their biomarker targets. Leighla graduated from the University of Colorado Boulder with majors in Neuroscience and Molecular, Cellular and Developmental Biology. After graduating, she started her career with Ionis 5 years ago as an Analytical Chemist in Pharmacokinetics. Her background in bioanalytical method development and regulatory requirements translated well as she’s taken on the development of biomarker assays. Leighla develops immunoassays for both non-clinical and clinical drug programs and is currently supporting the development of over 20+ biomarker targets.


The Impact of Matrix Selection as a Pre-Analytical Variable on BloodBased Protein Biomarker Quantification 1:15 pm

• In the context of protein biomarkers measurements, the goal is to measure the levels that are circulating • Understanding the impact of proper sample matrix selection is an important piece of this. Platelets and other circulating cells can release proteins during the process of coagulation • Anticoagulants can affect the ability to detect different…Read more

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