Joshua Xu

Joshua Xu

Company: U.S Food & Drug Administration

Job title: Branch Chief


11.45 | 8.45 – Establishing the Analytical Validity of Circulating Tumor DNA Sequencing for Precision Oncology 11:45 am

A multi-site, cross-platform evaluation of analytical performance among industry-leading ctDNA assays Sensitivity was highly variable for mutations present at variant allele frequencies below ~0.5%, especially when input material was limited Missed mutations (false-negatives) were more common than erroneous candidates (false-positives), indicating that the reliable sampling of rare ctDNA fragments is the key challenge for ctDNA…Read more

day: Day Three

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