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G. Mike Makrigiorgos

G. Mike Makrigiorgos

Company: Dana Farber Cancer Institute & Harvard Medical School

Job title: Professor


Dr. G. Mike Makrigiorgos is a Professor and Director of the Medical Physics & Biophysics Division in Radiation Oncology at Dana Farber Cancer Institute and Brigham and Women’s Hospitals, Harvard Medical School.  He is an ABR-certified radiation oncology physicist and he also directs his DNA technology laboratory and a radiation pre-clinical facility.  His current research interests include the development of novel DNA technologies for molecular diagnostics in Oncology and the detection of circulating cancer biomarkers.  Funded by the NCI continuously since 1994, his lab invented techniques for radiation dosimetry at the DNA level, low-level DNA mutation detection and tracing of circulating cancer biomarkers in blood. He is a Member of the Editorial Board of Clinical Chemistry and has published over 150 articles in journals including Nature Medicine, Nature Biotechnology, and Nature Communications.  He received his undergraduate degree in Physics from the University of Athens, Greece, his PhD in Medical Physics from the University of Leeds, UK and his postdoctoral training in radiation biology from Harvard Medical School, Boston.


Novel Digital PCR & Mutation Enrichment Technologies for the Analysis of Clinically Relevant DNA Alterations in Liquid Biopsies 12:00 pm

• With the increasing interest in treatment assessment using liquid biopsy and circulating DNA, sensitive and multiplexed detection of tumor-derived alterations in blood are desirable • We provide novel forms of digital PCR, as well as mutation enrichment-based real time PCR methods that (a) enable several orders of magnitude improvement of detecting mutations or microsatellite…Read more

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